2型糖尿病患者平均动脉压与臂踝脉搏波传导速度的相关性

目的:探讨2型糖尿病(T2DM)患者平均动脉压(MAP)与臂踝脉搏波传导速度(BaPWV)的相关性.方法:选取T2DM患者979例,应用电子血压计测量患者右上臂血压,计算MAP,采用三分位数法分为低MAP组(MAP<92.4 mmHg,n=327),中MAP组(92.4 mmHg≤MAP<102.4 mmHg,n=32...

Correlation between mean arterial pressure and brachial-ankle pulse wave velocity in patients with type 2 diabetes mellitus

Objective: To explore the correlation between mean arterial pressure (MAP) and brachial-ankle pulse wave velocity (BaPWV) in patients with type 2 diabetes mellitus（T2DM）. Methods: A total of 979 patients with T2DM were recruited for this study.  Electronic sphygmomanometer was used for measuring blood pressure in the right arms, and MAP was calculated. Based on MAP, patients were divided into low MAP group (MAP<92.4 mmHg, n=327), medium MAP group (92.4 mmHg ≤MAP<102.4 mmHg, n=326) and high MAP group (MAP≥102.4 mmHg, n=326). The BaPWV and ankle-brachial index were measured by Omron arteriosclerosis detector. The correlation between MAP and BaPWV were evaluated by multiple linear regression analysis and Logistic regression analysis. The ROC curve of MAP was drawn to evaluate its predictive value for arterial stiffness in T2DM. Results: BaPWV level was gradually elevated with MAP in T2DM patients (P<0.01). Correlation analysis indicated that MAP was positively correlated with age, body mass index, waist-to-hip ratio, insulin resistance index, triglyceride, and BaPWV. Multiple linear regression demonstrated that MAP was positively associated with BaPWV after adjustment for associated risk factors (P<0.01). Logistic regression analysis showed that MAP was independently associated with BaPWV in T2DM patients after adjustment for other confounders (OR=1.160，95%CI: 1.132-1.188). The area under the ROC curve of MAP for predicting arterial stiffness was 0.786 (95% CI: 0.759-0.811, P<0.01), and take the best cut off value of 94.4 mmHg (the sensitivity of was 75.0%, and the specificity was 69.2%). Conclusion: MAP is expected to be a simple and practical indicator to predict the risk of atherosclerosis in patients with T2DM. ［Key words］type 2 diabetes mellitus; arterial stiffness; brachial ankle pulse wave velocity; mean arterial pressure