Antigenicity of the phosphatidyl inositomannosides of mycobacteria. |
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| Authors: | B Banerjee D Subrahmanyam |
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| Affiliation: | 1. Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA;2. Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA;3. School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA;4. Nutrition Sciences Department, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA;5. Maryland Robotics Center, University of Maryland, College Park, MD, USA |
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| Abstract: | Purified di- and hexamannoside components ofMycobacterium 607 (M. 607) were analysed for their immunochemical relationships in agglutination and precipitation tests, using antisera against the MBSA complexes of total mannosides, M2-3F2 and M2-4F components of dimannosides. The agglutinating antibody to total mannosides seemed to be different from that given by the precipitation test. There was no cross-reactivity between PI and the mannoside antigens, which suggested the association of antigenicity with the mannose units of the mannosides. Dimannosides with 2, 3 and 4 esters showed complete cross-reactivity. However, different antigenic specificities were found to be associated with di- and hexamannoside antigens in the immunochemical reactions. The deacylated mannoside lacked serological reactivity with antiserum to the mannosides. However, the additional fatty acids in the inositol-oligomannosyl region of the dimannosides did not seem necessary for reactivity or specificity. |
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