急性有机磷中毒致循环衰竭的血流动力学变化

目的：研究急性有机磷中毒（AOPP）致循环衰竭患者的血流动力学变化。方法：总结26例AOPP致循环衰竭患者48h内的血流动力学变化，并分析生存者与死亡者的差别。结果：与正常参考均值比较：SVI、LVSWI在48h内显著降低（P％0．01）；RVSWI在24h内显著降低（P〈0．01）；CI在16h内显著降低（P〈0．01）。与同组2h比较，生存者的CI、SVI、LVswI／RVswI在24h后明显改善（P〈0．05或P〈0．01），血乳酸显著降低（P〈0．05或P〈0．01）；死亡者无改善。结论：AOPP致循环衰竭患者的心脏做功能力明显受损，治疗后生存者状况可以改善。

Hemodynamic changes in patients with circulatory failure induced by acute organophosphorus pesticide poisoning

Objective：To investigate hemodynamic changes in paitients with circulatory failure induced by acute organophosphorus pesticide poisoning （AOPP）. Method： To sum up the hemodynamic changes of 26 patients with circulatory failure induced by AOPP within 48 hours, and to analyze difference between survivors and non-survivors. Result：To compare with normal mean value：Stroke volume index（SVI） and Left ventricular stroke work index（LVSWI） significantly reduced（ P〈0.01） ; Right ventrieular stroke work index（RVSWl） significantly reduced within 24 hours（P〈0.01） ;Cardiac index（CI） significantly reduced within 16 hours（P〈0.01 ）. To compare with value of same group within 2 hours,CI and SVI and LVSWI/RVSWI of survivors significantly improved after 24 hours（P〈0.05 or P〈0.01）,blood lactate significantly reduced（P〈0.05 or P〈0.01）;but CI and SVI and LVSWI/RVSWI of non-survivors had not obviously improved. Conclusion： When circulatory failure happened, the working ability of the heart was significantly impaired. Treatment can improve cardiac function of survivors.