静脉应用阿米卡星和庆大霉素致骨骼肌强直痉挛各1例

例1,男,30岁。因＂呕吐腹泻5h＂就诊于一社区门诊,诊断为胃肠炎,应用阿米卡星500万U静脉滴注（静滴）,静滴完毕后约1h,在输用维生素C及维生素B6过程中突然出现面部、四肢骨胳肌强直收缩伴剧烈疼痛,难以忍受,故由＂120＂车接入我科。查体：T 37℃,P 82次/min,R 20次/min,BP165/90mmHg（1mmHg=0.133kPa）,发育正常,营养中等,神志清楚,语言欠清,抬入病房,查体合作。

Amikacin and gentamycin with venous application cause skeletal muscle tetanic convulsion in each cases

Gastroenteritis patients with intravenous application of aminoglycoside antibiotics appeared the facial and skeletal muscle tetanic convulsion and intense pain.No pathological sign appeared in these cases.The level of the leukocyte increased but the electrolyte was normal.Intravenous injection of diazepam can quickly relieve symptoms,no neurological sequelae were found.The diagnosis was aminoglycoside antibiotics adverse reactions.