Influence of estradiol on the benzo(a)pyrene hydroxylase activity induced by hexachlorocyclohexane |
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| Authors: | K M Munir U S Murdia S V Bhide |
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| Affiliation: | Carcinogenesis Division, Cancer Research Institute, Parel, Bombay 400 012 India |
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| Abstract: | Basal BP-hydroxylase activity was measured in male Swiss mice from the age of 3 weeks to 20 months. Maximal enzyme activity was at the age of 5 months. Comparison of the inducibility of BP-hydroxylase by HCH was also investigated in male and female mice of different ages. Male mice showed higher induction of BP-hydroxylase by HCH than females of the same ages. Sterilization of female mice enhanced enzyme induction. Estradiol exhibited competitive inhibition of BP-hydroxylase activity. After treatment with HCH for 8 months, female mice had a lower tumour incidence than males, and this paralleled a lower induction of BP-hydroxylase. |
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| Keywords: | Benzo(a)pyrene hydroxylase hexachlorocyclohexane estradiol B(a)P benzo(a)pyrenec BP-hydroxylase benzo(a)pyrene hydroxylase HCH hexachlorocyclohexane |
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