Affiliation: | a Facoltà di Farmacia, Università di Catanzaro, compl. Barbieri, 88021 Roccelletta di Borgia, Catanzaro (CZ), Italy b Dipartimento Farmaco-Chimico, Università di Messina, Facoltà di Farmacia, Vill. Annunziata, 98168, Messina (ME), Italy c Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Via Campi 183, 41100, Modena (MO), Italy |
Abstract: | Flavonoids are natural substances with a lot of biological activities, including the antioxidant one. Their use in pharmaceutical field is, however, limited by their aqueous insolubility. As the formation of the inclusion complexes can improve their solubility in water, the flavonoids hesperetin, hesperidin, naringenin and naringin have been complexed with β-cyclodextrin (β-CD) by the coprecipitation method and studied in solution and in solid state by NMR, FT-IR, differential scanning calorimetry and X-ray techniques. The effects of complexation on the chemical shifts of the internal and external protons of β-CD in the presence of each flavonoid were observed. |