ABCC11基因单核苷酸多态性与中国汉族人群腋臭发病的相关性研究

目的：研究我国汉族人群ABCC11基因的单核苷酸多态性与腋臭发病的关系。方法：应用高分辨率熔解曲线技术以及产物测序，检测40例腋臭患者及5例正常人ABCC11基因多态性位点rs17822931的基因型。结果：ABCC11基因多态性位点rs17822931的等位基因型检测发现腋臭患者37例为GA型，3例为GG型，5例正常人为AA型。结论：ABCC11基因的不同等位基因型决定腋臭的表型，GG或GA型表现为腋臭，AA型等位基因型则无腋臭。

Correlation between ABCC II gene single nucleotide polymorphism and the incidence of axillary osmidrosis in Chinese Han population

Objective：To explore the relationship between ABCC11 gene single nucleotide polymorphism （SNP） and the incidence of axillary osmidrosis in Chinese Han population.Methods：The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing. Results：hTe detection of the genotype of ABCC11 gene SNP at rs17822931 showed that：37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype. Conclusion：SNP in ABCC11 is the genetic cause of axillary osmidrosis. GG or GA leads to axillary osmidrosis, while AA allele presents the absence of axillary osmidrosis.