肝细胞肝癌患者血清AFP值影响因素的分析

目的 :了解肝细胞肝癌患者血清甲胎蛋白 (AFP)值并分析其影响因素。方法 :收集本院 1995年 1月至 1999年12月外科手术切除的 14 0例肝细胞肝癌患者的临床资料及术前AFP值 ,应用SPSS10 .0版软件进行多因素非条件logistic回归分析。结果 :所有肝细胞肝癌患者AFP阳性率为 62 .9% ,其中小肝癌AFP阳性率 5 2 .0 % ,显著低于巨大肝癌AFP阳性率73 .9% (P <0 .0 5 ) ;AFP值与肿瘤大小及肝硬化呈明显的相关性 (P <0 .0 5 )。结论 :AFP对诊断肝细胞肝癌 (特别是小肝癌 )的敏感性不高 ,需结合其它诊断措施。

Analysis of the influence factors of serum alpha-fetoprotein levels in patients with hepatocellular carcinoma

Objective To evaluate serum AFP levels and their influence factors in patients with hepatocellular carcinoma.Methods From January 1995 to December 1999,140 patients were subjected to hepatectomy in our hospital,AFP levels of the patients were evaluated.The data of the patients were analyzed by nonconditional logistic regression with SPSS10.0.Results The positive rate of AFP was 62.9% in patients with hepatocellular carcinoma.The positive rate of AFP of small hepatocellular carcinoma(52.0%) was significantly higher than that of large hepatocellular carcinoma (73.9%) ( P <0.05).It was showed that the AFP levels were related to tumor size and cirrhosis through logistic regression( P <0.05).Conclusion Sensitivity of AFP in hepatocellular carcinoma diagnosis,especially in small hepatocellular cancer was lower.It was notably increased when combined with other diagnostic methods.