20例结节性多动脉炎临床、病理分析

目的　探讨结节性多动脉炎 (Polyarteritisnodosa ,PA)的病理、病因 ,提高对本病诊断能力。 方法　收集和复习 2 0例病例的临床资料和病理切片 ,同时石蜡切片做PAS、PTAH、VG、IgG、IgM组织化学染色。 结果　发现PA是一类以动脉坏死为主要特征 ,累及全层动脉炎性病变 ,一些对纤维素是特异性的染色 ,在其坏死区或多或少地呈阳性 ,并IgG、IgM免疫组化染色见棕色颗粒。结论　PA是以纤维素样坏死为主要特征的临床疾病。其病因可能属变态反应性疾病。

Clinicopathologic Analysis of 20 Cases of Polyarteritis Nodosa

Objective To investigate the pathology and pathogenesis of the polyarteritis nodosa and to improve its diagnosis.Methods Samples of 20 cases were studied with the histochemical staining and microscopic examination.Clinical data were gathered for comprehensive analysis.Results Polyarteritis nodosa were mainly characterized by necrosis and inflanmation of arteries.Histochemical staining of fibrin and immunohistochemical staining of IgG and IgM were positive.Conclusions Polyarteritis nodosa were mainly characterized by arterial necrosis and arteritis.It may be considered as an allergic disease.