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In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335 |
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| Authors: | Lagacé Lisette White Peter W Bousquet Christiane Dansereau Nathalie Dô Florence Llinas-Brunet Montse Marquis Martin Massariol Marie-Josée Maurice Roger Spickler Catherine Thibeault Diane Triki Ibtissem Zhao Songping Kukolj George |
| Affiliation: | Boehringer Ingelheim (Canada) Ltd., Laval, Québec, Canada H7S2G5. |
| Abstract: | The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts in sensitivity specific to BI 201335 that did not alter susceptibility to alpha interferon. In contrast to macrocyclic and covalent protease inhibitors, changes at V36, T54, F43, and Q80 did not confer resistance to BI 201335. |
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