Aggregates of denatured proteins stimulate nitric oxide and superoxide production in macrophages |
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| Authors: | Szczepan Jozefowski Janusz Marcinkiewicz |
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| Institution: | (1) Department of Immunology, Jagiellonian University School of Medicine, Czysta 18 St., 31-121 Cracow, Poland;(2) Department of Cell Biology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland |
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| Abstract: | Objective Denatured proteins are deposited in damaged tissues, around implanted biomaterials, during natural aging as well as in a heterogeneous
group of amyloid diseases, such as Alzheimer’s disease. There is evidence that tissue damage observed in amyloidosis is mediated
mainly by factors released from activated macrophages, such as superoxide and nitric oxide (NO), as opposed to direct interaction
between amyloid fibrils and nonimmune cells. |
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