铜绿假单胞菌注射液治疗乳腺癌癌性溃疡的临床研究

目的研究铜绿假单胞菌注射液治疗乳腺癌癌性溃疡的有效性和不良反应。方法乳腺癌癌性溃疡患者14例，采取不同的治疗方法：单纯化疗（对照组）6例，铜绿假单胞菌注射液联合化疗（治疗组）7例，单独给予铜绿假单胞菌注射液1例。分男13测量治疗前后渍疡及肿块大小，观察铜绿假单胞菌注射液在乳腺癌癌性渍疡治疗中可能出现的不良反应。结果铜绿假单胞菌注射液联合化疗治疗组对乳腺癌癌性溃疡疗效优于单纯化疗组，差别有统计学意义（P〈0．05），单独应用铜绿假单胞菌注射液对乳腺癌癌性溃疡也有一定的治疗作用。治疗过程中除发热外无明显不良反应发生。结论铜绿假单胞菌注射液治疗乳腺癌癌性溃疡面愈合安全而有效。

PA-MSHA injection for malignant ulcer in breast cancer

Objective To evaluate the effectiveness and safety of PA-MSHA injection for malignant ulcer in breast cancer. Methods Fourteen patients with malignant ulcer of breast cancer were randomly assigned to receive chemotherapy alone （control group, n ： 6）, or combined with PA-MSHA injection （experimental group, n = 7）, or PAMSHA alone （n=1）. Tumor volume and ulcer area were measured before and after the treatment. The adverse reactions were also evaluated after the therapy. Results The response rate （CR＋PR） was 85.7% in the experimental group and 33% in the control group （P〈0.05）. PA-MSHA alone can take effect in the cure of malignant ulcer in breast cancer. Except fever, there was no significant adverse effect during the PA-MSHA treatment. Conclusion PA-MSHA injection is effective and safe for malignant ulcer in breast cancer.