IL-6、PTC和CRP联合检测在新生儿败血症诊断中的价值分析

目的：研究血清白介素-6（IL-6）、降钙素原（PTC）、C反应蛋白（cRP）联合检测在新生儿败血症诊断中的价值。方法：将100例新生儿败血症患者纳入观察组，同期分娩的100例健康新生儿纳入对照组，采集外周血检测血清IL-6、PTC和CRP水平，并通过序贯器官功能衰竭评估（SOFA）评分、危重评分系统（PCIS）评分判断全身情况。结果：（1）观察组患儿IL-6、PTC、CRP水平高于对照组（P〈0．05），3项指标联合检测的灵敏度、特异性、阳性预测值、阴性预测值分别为94．00％、98．00％、97．92％、94．23％；（2）观察组患儿SOFA评分高于对照组（P〈0．05），PCIS评分低于对照组（P〈0．05）；（3）IL-6、PCT、CRP水平与SOFA评分呈正相关，与PCIS评分呈负相关。结论：新生儿败血症患者的IL-6、PCT、CRP水平明显升高，3项指标联合检测可提高灵敏度和特异性，且与疾病的严重程度密切相关，是理想的实验室检查指标。

Clinical value of IL-6, PTC,CRP combined detection in diagnosis of neonatal sepsis

Objective： To study the clinical value of IL-6, PTC, CRP combined detection in diagnosis of neonatal sepsis s. Methods： 100 cases of neonatal sepsis patients were enrolled in the observation group and 100 cases of newborn infants during the same period were enrolled in control group. Then serum IL-6, PTC, CRP levels were detected, general condition were measured by SOFA score and PCIS score. Results： IL-6, PTC, CRP levels of observation group were higher than those of con- trol group; sensitivity, specificity, positive predictive value, negative predictive value of combined detection were 94.00%, 98.00% ,97. 92%, 94. 23%, respectively. SOFA scores of observation group were higher than those of control group, PCIS scores were lower than those of controI group. IL-6, PTC, CRP levels were positively correlated with SOFA score and nega tively correlated with PCIS score. Conclusion： IL-6, PTC, CRP levels are significantly increased in neonatal sepsis, combined detection can improve sensitivity, specificity and closely related to the severity of disease.