SphK1蛋白在胃癌组织中的表达及临床意义

目的：检测鞘氨醇激酶1型（SphK1）在胃癌组织中的表达情况并分析其临床意义。方法：采用免疫组织化学染色检测58例胃癌及对应癌旁组织中SphK1蛋白的表达情况，分析SphK1蛋白表达与胃癌不同临床病例参数之间的相关性。结果：SphK1蛋白在胃癌组织中的阳性表达率与对应癌旁组织中SphK1蛋白的阳性表达率比较，差异有统计学意义（P〈0．05）。胃癌组织中SphK1蛋白表达与浸润深度、淋巴结转移和TNM分期有关。结论：胃癌组织中SphK1蛋白高表达，其高表达与恶性临床病理参数密切相关，提示SphK1在胃癌发生发展中可能发挥重要作用。

Evaluation of SphK1 protein expression and its clinical significance in gastric cancer tissues

Objective： To explore the expression of SphK1 and its clinical significance in gastric cancer tissues. Methods： A total of 58 samples of surgically reseeted gastric cancer and matched normal tumor-adjacent tissues were subjected to immunohistochemistry for SphK1 protein detection. Correlation between SphK1 protein expression and different clinicopathological features in gastric cancer was analyzed. Results： Positive expression rate of SphK1 protein was 79.3% （46/58） in gastric cancer tissues and was 24.1% （14/58） in matched normal-adjacent tissues, the difference was significantly （χ^2 = 35. 352, P = 0. 000）. The expression of SphK1 protein was significantly correlated with depth of infiltration （χ^2 = 4. 312;P= 0. 038）, occurrence of lymph node metastasis （χ^2=7.459;P=0.006） and TNM tumor stage （χ^2=4.156;P=0.041）. Conclusion： The expression of SphK1 is elevated and its high-expression is associated with poor clinicopathological parameters in gastric cancer tis sues, suggesting SphK1 may promote tumour progression in gastric cancer.