| 基底外侧杏仁核中5—羟色胺抗抑郁作用的研究 |
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| 引用本文： | 钟明奎,何延龙,等.基底外侧杏仁核中5—羟色胺抗抑郁作用的研究[J].中国行为医学科学,2001,10(4):284-285. |
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| 作者姓名： | 钟明奎 何延龙 |
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| 作者单位： | 钟明奎（安徽医科大学生理教研室安徽合肥 230032）
何延龙（安徽医科大学生理教研室安徽合肥 230032）
张景行（安徽医科大学生理教研室安徽合肥 230032）
朱国庆（安徽医科大学生理教研室安徽合肥 230032）
赵乐章（安徽医科大学生理教研室安徽合肥 230032） |
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| 基金项目： | 安徽省教委自然科学基金资助项目(2000j1096);安徽医科大学科研基金 |
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| 摘 要： | 目的：研究大鼠基底外侧杏仁核（BLN）中5－羟色胺（5－HT）的抗抑郁作用。方法：运用立体定位技术进行核团内微量注射，通过开野实验和强迫游泳实验及多导睡眠描记（PSG）等方法观察大鼠的行为和睡眠的变化。结果：BLN内微量注射5－HT前体5－羟色氨酸（5－HTP），可使大鼠自主活动增加和强迫游泳不动时间缩短，并引起慢波睡眠（SWS）和异相睡眠量（PS）增多。5－HT受体阻断剂麦角新碱（MS）的效应与5－HTP相反，并可阻断5－HTP的作用。结论：增加大鼠BLN内5－HT含量可引起行为活动增加和睡眠增多，表明BLN内5－HT具有明显的抗抑郁作用。
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| 关 键 词： | 5－羟色胺 杏仁核 抗抑郁 药理 治疗 |
| 文章编号： | 1005-8559(2001)04-0284-02 |
| 修稿时间： | 2000年11月23 |
The antidepressant effect of serotonin in hasolateral amygdaloid nuclei |
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| ZHONG Mi ng-kui,HE Yan-long,ZHANG Jing-xing,et al..The antidepressant effect of serotonin in hasolateral amygdaloid nuclei[J].Chinese Journal of Behavioral Medical Science,2001,10(4):284-285. |
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| Authors: | ZHONG Mi ng-kui HE Yan-long ZHANG Jing-xing |
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| Institution: | ZHONG Mi ng-kui,HE Yan-long,ZHANG Jing-xing,et al. Department of Physiology,Anhui Medical University,Hefei 230032 |
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| Abstract: | Objective To study the antidepressant effect of serotonin(5-HT) in bas olateral amygdaloid nuclei(BLN). Methods Microinjection i nto the nuclei by stero taxic surgery, open field activity(OFA), forced swimming test (FST) and polysomn ography(PSG) were applied to investigate the behavioral activity and sleep of ra ts. Results Microinjection of 5-hydroxytryptaphan (5-HT P), the immediate precursor of 5-HT, into BLN increased locomotor activity in OFA , reduced immobility t ime in FST and prolonged both slow wave sleep (SWS) and paradoxical sleep (PS). The effects of 5-HTP could be abolished by Methysergide (MS), an antagonist of 5 -HT receptor. Conclusion Enhancement of content of 5-HT in BLN could promote be havioral activity and sleep obviously and had remarkable antidepressant effects. |
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| Keywords: | Serotonin Amygdaloid nuclei Anti-depressio |
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