IgA肾病患者的扁桃体免疫组织化学观察

目的：了解ＩｇＡ肾病（ＩｇＡ－Ｎ）与扁桃体免疫异常的关系。方法：经肾穿刺活检确诊为ＩｇＡ－Ｎ３１例，以慢性扁桃体炎１６例作对照，扁桃体切除术后运用ＡＢＣ方法对扁桃体组织进行免疫组化标记。结果：两组扁桃体在ＩｇＡ、ＩｇＧ的表达上存在明显的区别，ＩｇＡ－Ｎ患者的扁桃体组织内产生ＩｇＡ的淋巴细胞数显著增加，结论：ＩｇＡ－Ｎ患者存在着扁桃体免疫异常，切除扁桃可预防抗原入浸，消除扁桃体来源的ＩｇＡ，减少循环中的ＩｇＡ免疫复合物形成，进一步使肾小球基底膜区的ＩｇＡ免疫复合物沉积减少。

Immunohistological observation of tonsillae in IgA nephropathy

Objective:To realize the relationship between IgA nephropathy (IgA N) and immunological abnormality of tonsillae.Method:Thirty one patients were diagnosed as IgA N via renal puncture.Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method.Result:The differences of expression of IgA,IgG in the tonsillae between above two groups were significantly obvious.The number of lymphocytes which can produce IgA increased in IgA N tonsillae.Conclusion:The immune functions are abnormal in IgA N patients. Tonsillectomy can prevent the antigen invasion,eliminate IgA originated from tonsillae,decrease the IgA immunocomplex in circulation,therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.