ClinicalControlled Study of Shenmai Injection(参麦注射液)and Aminophylline on DiaphragmFatigue

Clinical controlled study of shenmai injection and aminophylline on diaphragm fatigue

Objective: To compare the therapeutic effect of Shenmai injection (SM) and aminophylline (AP) on diaphragm fatigue in chronic obstructive pulmonary disease ( COPD ).Methods: Sixty-four COPD patients with respiratory failure and diaphragm fatigue were randomly divided into 2 groups. The SM group (n=33) was treated with oxygen inhalation, anti-infection agents, and SM injection (SM 40ml + 10% glucose 100ml). The AP group (n=31) was treated by the same comprehensive treatment but with AP 0. 25g instead of SM. The initial time of diaphragm fatigue disappearance, 24 hrs maintaining effect and the arterial blood gas analysis were observed.Results: The effect in 30 min and maintaining effect in 24 hrs in SM group were better than those in AP group. In both groups, PaO₂ increased and PaCO₂ decreased.Conclusion: The therapeutic effect of SM on COPD patients with respiratory failure and diaphragm fatigue was better than those of AP.