美沙拉嗪口服联合中药灌肠治疗溃疡性结肠炎临床观察

目的观察美沙拉嗪口服联合中药灌肠治疗溃疡性结肠炎的临床疗效。方法 65例患者随机分为治疗组35例,用美沙拉嗪口服联合中药保留灌肠,对照组30例用SASP口服及保留灌肠,观察两组临床症状、结肠黏膜的改善情况及不良反应。结果治疗组和对照组的总有效率分别为94.3%和73.3%,两组临床疗效比较有显著性差异（P〈0.05）,治疗组症状及结肠黏膜的改善情况优于对照组（P〈0.05）,治疗组与对照组的不良反应比较有高度显著性差异（P〈0.01）。结论美沙拉嗪口服联合中药保留灌肠治疗溃疡性结肠炎安全有效。

Curative effects of mesalazine PO in combination with Chinese medicine enema on treatment of ulcerative colitis

Objective To investigate the clinical efficacy of mesalazine PO in combination with Chinese medicine enema on ulcerative colitis（UC）.Methods 65 patients were randomly divided into two groups.The 35 in treatment group were treated with mesalazine PO and Chinese medicine retention enema.The other 30 in control group were treated with SASP PO as well as retention enema.The differences of clinical symptoms,the variation of colonic mucosa and adverse reactions were observed before and after the treatment.Results The total effective rate in treatment group and control group was 94.3% and 73.3% respectively.The clinical efficacy of two groups was significant difference（P 0.05）.The improvement of symptoms and colonic mucosa was superior than the control group（P 0.05）.There was a very significant difference between treatment group and control group in adverse drug reactions.（P 0.01）.Conclusion Mesalazine PO in combination with Chinese medicine enema has a safe and obvious therapeutic efficacy on ulcerative colitis.