结肠癌及癌旁组织中P16和CDK4的表达

目的：研究结肠癌及癌旁组织中P16和CDK4的表达,了解其与结肠癌的关系。方法：用免疫组织化学方法检测50例结肠癌和相应癌旁组织中P16和CDK4的表达。结果：1.结肠癌旁组织中P16阳性表达率明显高于癌组织;随着Dukes分期越高、淋巴结的转移、癌组织分化程度越低、组织浸润深度越深P16阳性表达越来越低。2.结肠癌旁组织中CDK4低表达,而结肠癌组织中CDK4高表达;Dukes分期越高、结肠癌恶性度越高、癌组织分化程度越低、组织浸润深度越深CDK4的阳性表达率越高;伴有淋巴结转移的CDK4阳性表达率较无淋巴结转移的阳性表达率高。结论：P16和CDK4可能与结肠癌的发生密切相关。

Expression of P16 and CDK4 in colonic carcinoma and pericancerous Mucosa

Objective： To studay the expression of P16 and CDK4 in colonic carcinoma and pericancerous mucosa and the relation ship between which and colonic carcinoma. Methods： The expression of P16 and CDK4 were determined by immunohistoehemistry in 50 cases of human colon carcinoma and tissue adjacent to colon carcinoma. Results： The expression rate of P16 in tissue adjacent to colon carcinoma is markly highter than in carcinoma. The higher Duke＇s stage, the more lymph node metastasis, the lower differentiated stage of cancerous tissue, the deeper invasive depth of tissue, the positive rate of P16 expression is lower. The expression of CDK4 in tissue adjacent to carcinoma is lower, however in colon carcinoma which is expressed higher. As the higher Duke＇ s stage, the higher malignant grade, the lower differentiated stage of cancerous tissue, the deeper invasive depth of tissue, the positive rate of CDK4 expression is higher; positive rate of CDK4 in colonic carcinoma with lymph node metastasis is higher than which without lymph node metastasis. Conclusion： P16 and CDK4 are close with colon carcinoma.