Glucose-induced insulin response and insulin sensitivity is not related to HLA-type but to age in young siblings of Type 1 (insulin-dependent) diabetic patients |
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| Authors: | F. Lindgren G. Dahlquist S. Efendic' E. Möller B. Persson B. Thalme M. Landin Olsson |
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| Affiliation: | (1) Department of Pediatrics, Karolinska Institute, Sachs' Children's Hospital, Stockholm;(2) Department of Endocrinology, Karolinska Institute, Karolinska Hospital, Stockholm;(3) Department of Pediatrics, Karolinska Institute, St. Görans Hospital, Stockholm;(4) Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Huddinge;(5) Department of Pediatrics, Karolinska Institute, Huddinge Hospital, Huddinge;(6) Department of Internal Medicine, Malmö University Hospital, Malmö, Sweden |
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| Abstract: | Summary Glucose-induced insulin response and insulin sensitivity were studied in 32 HLA-identical, 38 haplo-identical and 24 non-identical, islet-cell-antibody-negative, healthy siblings of young Type 1 (insulin-dependent) diabetic patients (age range 10–28 years). No significant differences were obtained between HLA-identical, HLA-haplo-identical siblings and HLA-non-identical siblings in insulin response using an i.v. glucose infusion test even when the insulin sensitivity as estimated by the somatostatin-insulin-glucose infusion test was taken into account. A significant inverse correlation to age was found for both insulin response (r=-0.24, p=0.02) and insulin sensitivity (r=-0.36, p<0.01) in the young siblings studied. |
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| Keywords: | Type 1 (insulin-dependent) diabetes mellitus etiology siblings HLA-types glucose tolerance test insulin resistance age |
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