| Abstract: | Stromal fibroblasts from monolayer cultures of thymus, spleen, and bone marrow cells, when added to nonadherent suspension cultures of spleen cells have a significant influence on the accumulation of antibody-forming cells (AFC). Stromal fibroblasts of thymic origin stimulate-AFC formation, whereas those of bone-marrow origin inhibit antibody formation in these cultures. Stromal fibroblasts of splenic origin have the same effect on AFC formation as adherent cells. Stromal fibroblasts irradiated in a dose of 5000 R have the same action as unirradiated cells. The action of stromal fibroblasts on antibody formation in culture is manifested only if they adhere to the surface of the culture vessel.Laboratory of Immunomorphology, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR P. A. Vershilova.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 6, pp. 699–701, June, 1978. |
