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| 骨髓间充质干细胞向雪旺细胞诱导分化方法的研究进展 | |
| 引用本文： | 李爽,马信龙,马剑雄,孙晓雷. 骨髓间充质干细胞向雪旺细胞诱导分化方法的研究进展[J]. 国际生物医学工程杂志, 2011, 34(4): 227-231. DOI: 10.3760/cma.j.issn.1673-4181.2011.04.009 |
| 作者姓名： | 李爽 马信龙 马剑雄 孙晓雷 |
| 作者单位： | 1. 300052,天津医科大学总医院骨科 2. 300052 天津医科大学总医院骨科;300211 天津市天津医院 3. 300211,天津市天津医院 |
| 基金项目： | 天津市科委应用基础与前沿技术研究计划重点项目(09JCZD19600)；天津市卫生局科研基金项目 |
| 摘 要： | 细胞移植技术治疗周围神经损伤已成为新兴的组织工程学研究热点。骨髓间充质干细胞(BMSCs)，由于其具有扩增快、便于分离提纯、可以体外诱导分化成为雪旺细胞(SC)的特性，有可能成为雪旺细胞的有效替代品和组织T程化神经的新型种子细胞。就种子细胞雪旺细胞和骨髓间充质干细胞的生理功能、生物学特性、体外诱导骨髓间充质干细胞生成雪... |
| 关 键 词： | 雪旺细胞 骨髓间充质干细胞 诱导分化 组织工程 |
Research progress on differentiation of bone marrow stem cell into Schwann cells |
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| LI Shuang,MA Xin-long,MA Jian-xiong,SUN Xiao-lei. Research progress on differentiation of bone marrow stem cell into Schwann cells[J]. International Journal of Biomedical Engineering, 2011, 34(4): 227-231. DOI: 10.3760/cma.j.issn.1673-4181.2011.04.009 | |
| Authors: | LI Shuang MA Xin-long MA Jian-xiong SUN Xiao-lei |
| Affiliation: | .(Department of Orthopaedics, General Hospital of Tianjin Medical University, Tianjin 300052, China) |
| Abstract: | Applying cellular transplant methods in the treatment of peripheral nerve injury has become a new hot spot in tissue engineering and drawn much attention. Bone marrow stromal cells (BMSCs) grow fast and can be easily purified in vitro. Besides, they have the capability of differentiating into Schwann cells under specific conditions. For all the reasons above, BMSCs are considered good succedaneum of Schwann cells and new seed cells for tissue engineered peripheral nerve. In this review, the physiological functions and bionomics of Schwann cells and BMSCs are introduced, as well as various methods inducing BMSCs into nerve tissue cells and the foreground of the research. |
| Keywords: | Schwann Bone marrow mesenchymal stem cells Differentiate Tissue engineering |
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