吲哚美辛对重症急性胰腺炎大鼠腹腔器官血流的影响

目的：研究吲哚美辛对重症急性胰腺炎（SAP）大鼠腹腔器官血流，特别是胰腺血流的影响及其作用机制。方法：将大鼠随机分成吲哚美辛治疗组（IN）和重症急性胰腺炎组（SAP）；各组分别有数只大鼠于术后12、24h处死，观察血浆淀粉酶的变化。另设正常对照组。运用多普勒超声测定胰腺局部动脉（相当于胰头、体交界处）、门静脉血流、脾动脉及肠系膜上动脉血流。结果：IN组的血浆淀粉酶明显低于SAP组（P〈0．01）。SAP时，大鼠胰腺局部动脉血流明显下降，且于术后12h时已呈明显下降（与对照组比较P〈0．01）。随胰腺炎的病程进展，胰腺局部血流的下降也更趋严重（24h与12h比较，P〈0．05）。与此同时，门静脉、脾动脉和肠系膜上动脉的血流量也行下降（与对照组比较，P〈0．01）。应用吲哚美辛能改善胰腺、门静脉、脾动脉及肠系膜上动脉的血流量（与SAP组比较，P〈0.01）。结论：吲哚美辛能促使SAP大鼠胰腺血流量增加。

Effect of indomethacin on the splanchnic blood flow in rats with severe acute pancreatitis

Objective To investigate the role of indomethacin on the splanchnic blood flow in severe acute pancrea-titis(SAP) rats and to elucidate the underlying mechanism.Methods Forty-eight rats were randomly divided into 2 groups: indomethacin group(IN group,n=24) and SAP group(n=24).Jejunotomy was performed in all.IN group received indomethacin;SAP group received saline.All groups were subdivided into 2 subgroups;and other 8 normal rats were used as controls.At 12,24 hours after the induction of SAP,12 rats in each group were sacrificed.Serum amylase was measured.The regional pancreatic blood flow was measured by Doppler ultrasound;the blood flow of portal vein,spleen artery and superior mesenteric artery were also measured.Results The level of the serum amylase was lower in the IN group than that in the SAP group(P<0.01).The regional pancreatic blood flow was decreased significantly in the SAP group(P<0.01),and continued to decrease after 24 h(vs12 h,P<0.01).The blood flow of the portal vein,spleen artery and superior mesenteric artery were also decreased in the SAP group.Indomethacin could increase the regional pancreatic blood flow,as well as the blood flow of the portal vein,spleen artery and superior mesenteric artery(vs SAP group,P<0.01).Conclusions Enteral administration of indomethacin could increase the splanchnic blood flow in SAP rats.