Prefrontal cortex lesions attenuate substantia nigra self-stimulation: a reward summation analysis |
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Authors: | J A Silverman D Corbett |
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Institution: | University of Pittsburgh School of Medicine, PA. |
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Abstract: | A curve-shift paradigm was used to assess the effects of lesions of the prefrontal cortex on self-stimulation from electrode sites in the substantia nigra. Combined lesions of the medial and sulcal cortical regions severely attenuated substantia nigra self-stimulation. These results are discussed in the context of the frontal cortex and the substantia nigra as belonging to a reinforcement system that is largely independent of the medial forebrain bundle system. |
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