| Alteration of Excitatory Amino Acid in Experimental Spinal Cord Injury in Rats |
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| 作者姓名： | 张宁 罗永湘 |
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| 作者单位： | Department of Orthopaedics，the First Affiliated Hospital of Nanjing Medical University，Affiliated Tongji Hospital of Tongji Medical College，Huazhong University of Science and Technology Nanjing 210029，Wuhan 430030，P. R. China |
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| 摘 要： | Objective To detect the effect of excitatory ammo add (EAA) in the secondary damage following spinal cord injury (SCI). Methods Glutamate (Glu) and Aspartate (Asp) on the injury site (T8) were studied using a rat SCI model induced by Allen's weight drop method (10g×2. 5cm). The result suggested that Asp and Glu were significantly increased in 10 mm. Results Glu was significantly decreased from 2 h to 24 h,while Asp was a tittle reduced in 2 h,and slightly rose in 4 h as compared with Control Group. Though elevated in 8 h,it dropped again in 24h as compared with Control Group. Conclusion The result indicates that the rise of EAA following SCI could be the cause of the secondary spinal cord damage.
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| 关 键 词： | 大鼠 实验性脊髓损伤 兴奋性氨基酸 二次损伤 病理 |
Alteration of Excitatory Amino Acid in Experimental Spinal Cord Injury in Rats |
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| ZHANG Ning,LUO Yong-xiang.Alteration of Excitatory Amino Acid in Experimental Spinal Cord Injury in Rats[J].Journal of Nanjing Medical University,2002,16(4):179-181. |
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| Authors: | ZHANG Ning LUO Yong-xiang |
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| Institution: | 1. Department of Orthopaedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing,210029
2. Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030,P. R. China |
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| Abstract: | Objective To detect the effect of excitatory amino acid (EAA) in the sec-ondary damage following spinal cord injury (SCI). Methods Glutamate (Glu) and Aspartate(Asp) on the injury site (T8) were studied using a rat SCI model induced by Allen's weight drop method(10g×2.5cm). The result suggested that Asp and Glu were significantly increased in 10 min. Re-sults Glu was significantly decreased from 2 h to 24 h,while Asp was a little reduced in 2 h,andslightly rose in 4 h as compared with Control Group. Though elevated in 8 h, it dropped again in 24 h ascompared with Control Group. Conclusion The result indicates that the rise of EAA following SCIcould be the cause of the secondary spinal cord damage. |
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| Keywords: | spinal cord injury excitatory amino acid glutamate animal experi-ment rats |
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