周剂量多西紫杉醇联合顺铂和氟尿嘧啶治疗晚期胃癌

目的 观察周剂量多西紫杉醇联合顺铂和氟尿嘧啶方案治疗晚期胃癌的临床疗效和毒性反应.方法 晚期胃癌患者31例,给予多西紫杉醇35 mg/m2,静脉滴注1 h,第1、8、15天;顺铂20 mg/m2,静脉滴注4 h,第2～6天;5-氟尿嘧啶750 mg/m2,持续静脉滴注24 h,第2～6天;28 d为一周期,至少治疗2个周期,按标准评价疗效和毒性反应.结果 全组31例均可评价疗效,总有效率为48.4%,其中17例初治患者有效率为64.7%,CR 2例;14例复治患者有效率为28.6%.中位肿瘤进展时间6个月,中位生存期11个月,1年生存率41.9%.主要毒性反应为骨髓抑制、消化道反应和脱发,多数为1～2 度.结论 周剂量多西紫杉醇联合顺铂和氟尿嘧啶治疗晚期胃癌疗效较好,毒性反应较轻,耐受性好.

Weekly dosage of docetaxel combined with cisplatin and 5-fluororacil in the treatment of advanced gastric cancer

Objective To observe the effects and toxicity of docetaxel given once weekly combined with cisplatin and 5-fluororacil in the treatment of advanced gastric cancer(AGC).Methods Thirty-one patients with AGC were given docetaxel at 35 mg/m2 by intravenous infusion completed in 1 h on the 1st,8th and 15th days.Cisplatin was given at 20 mg/m2 for 4 h between the 2nd and 6th days,during which time 5-fluororacil was also given at 750 mg/m2 for 24 h.One treatment cycle lasted for 28 days and 2 consecutive cycles were administered.Results In the 31 patients available for therapeutic effect evaluation,the overall effective rate was 48.4%.The effective rate in patients without previous treatments was 64.7%(CR in 2 cases),and 28.6% in the retreated patients.The median TTP,median survival time and one-year survival rate were 6 months,11 months and 41.9%,respectively.The main toxic reactions of the combined treatment were myelosuppression,gastrointestinal tract reaction and alopecia of mostly grade 1 or 2.Conclusion Weekly dosage of docetaxel combined with cisplatin and 5-fluororacil is an effective regimen for AGC with only mild toxic reactions and good patient tolerance.