碳包铁纳米晶急性毒性实验及其对肝肾功能和血液系统的影响

目的 分析碳包铁纳米晶(CCIN)的急性毒性及其对肝肾功能和血液系统的影响.方法 经小鼠尾静脉分别注入不同剂量的CCIN粒子,观察小鼠14 d内的急性毒性反应;经大鼠尾静脉分别注入高、中、低剂量CCIN粒子及对照组注入生理盐水,分别于给药前1 d,给药后第1、3、7、14天检测大鼠肝肾功能及血常规.结果 小鼠静脉注射CCIN粒子的LD50=203.8mg/kg;当大鼠静脉注入CCIN 80mg/kg以内时,无动物死亡,肝肾功能、血液系统可能会有一过性轻微损害,但2周内一般可自行恢复.结论 CCIN粒子毒性较低,在一定剂量范围内对肝肾功能及血液系统影响不大.

Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system

Objective To study the acute toxicity of carbon-coated iron nanocrystal (CCIN) in mice and its effects on hepatic, renal and hematological functions. Methods Acute toxicity of CCIN was evaluated by observing the toxic reactions in mice within 14 days following intravenous injection of different doses of CCIN particles. The liver and kidney functions and blood chemistry were tested in rats before and at different time points after CCIN injection. Results The median lethal dose (LD50) of CCIN particles given by intravenous injection was 203.8 mg/kg in mice. Within the intravenous dose of 80 mg/kg injection, CCIN caused only mild alterations of the rats' biochemical and hematological indices that recovered without intervention in two weeks. Conclusion CCIN is characterized by low acute toxicity and mild side effects on the hepatic, renal and hematological functions within a certain dose range.