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血红素氧化酶基因启动子GT序列变化与冠状动脉支架术后再狭窄
引用本文:李萍,Jutta Palmen,Emma Hawe,Kim M. Fox. 血红素氧化酶基因启动子GT序列变化与冠状动脉支架术后再狭窄[J]. 中国循环杂志, 2006, 21(2): 113-116
作者姓名:李萍  Jutta Palmen  Emma Hawe  Kim M. Fox
作者单位:1. 330006,江西省南昌市,南昌大学第二附属医院心内科
2. Centre for Cardiovascular Genetics,BHFlaboratories,University College London
3. Heart and Lung Institute and Royal Brompton Hospital
摘    要:目的:观察I型血红素氧化酶(HO-1)基因启动子GT重复长短对冠状动脉支架置入术后再狭窄的影响。方法:187例行冠状动脉支架置入术者,6个月时随访再狭窄情况。PCR和DNA测序仪确定HO-1启动子GT重复次数。高敏法测术前及术后24h、48h血浆白介素-6(IL-6)和C反应蛋白(CRP)值。结果:各基因型间术后IL-6和CRP水平及再狭窄发生率无差异,携较短GT者术前血浆IL-6水平比非短GT序列携带者低约33.3%(P=0.0008)。结论:HO-1基因多态性不影响支架置入术后炎症介质水平及再狭窄,但可能影响动脉粥样硬化形成的炎症过程。

关 键 词:血红素氧化酶  GT重复序列  再狭窄
文章编号:1000-3614(2005)02-113-04
修稿时间:2005-11-16

(GT)n Repeats Variation on Promoter Region of Heme-Oxygenase-1 and Restenosis After Coronary in-Stenting
LI Ping,Mohamed A. Elrayess,Abuzeid H. Gomma,Jutta Palmen,Emma Hawe,Kim M. Fox,Steve E. Humphries. (GT)n Repeats Variation on Promoter Region of Heme-Oxygenase-1 and Restenosis After Coronary in-Stenting[J]. Chinese Circulation Journal, 2006, 21(2): 113-116
Authors:LI Ping  Mohamed A. Elrayess  Abuzeid H. Gomma  Jutta Palmen  Emma Hawe  Kim M. Fox  Steve E. Humphries
Abstract:Objective:The promoter region of heme-oxygenase-1 ( HO-1) shows a polymorphism which carries different ( GT) n repeats that have been reported to differently induce gene expression. The purpose of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods:One hundred and eighty-seven patients who underwent coronary stent implantation were followed up for restenosis at 6 months. The HO-1 genotype was determined using PCR and automated DNA capillary sequencing. Plasma levels of IL-6 and C-reactive protein (CRP) were obtained at baseline,24 and 48 h after stenting. Results: There was no difference in the restenosis between the genotype groups or postoperative levels of inflammation markers ( IL-6 and CRP ), but carriers with S allele had a 33.3% baseline IL-6 reduction compared with non-S carriers (P = 0.0008). Conclusion:The association of HO-1 promoter polymorphism with baseline plasma IL-6 levels suggests that HO-1 S allele might influence the atherosclerotic inflammatory process.
Keywords:Heme-oxygenase  Polymorphism  Restenosis
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