| 幽门螺杆菌在胃癌发生过程中的作用初探 |
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| 引用本文： | 蔡嵘,任刚,陈强. 幽门螺杆菌在胃癌发生过程中的作用初探[J]. 肿瘤, 2000, 20(3): 209-211 |
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| 作者姓名： | 蔡嵘 任刚 陈强 |
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| 作者单位： | ： |
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| 基金项目： | 卫生部基金!(962281)，上海市科委基金!(964L11)资助项目 |
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| 摘 要： | 目的 探讨Ｈｐ感染在胃癌及癌前病变中的作用机制。方法 应用分子生物学方法检测ｃ－Ｈａ－ｒａｓ和ｐ５３基因点突变。结果Ｈｐ阳性患者ｃ－Ｈａ－ｒａｓ和ｐ５３基因的突变发生率明显高于Ｈｐ阴性患者；胃癌组Ｈｐ阳性患者中ｃ－Ｈａ－ｒｓａ和ｐ５３的突变率显著高于阴性患者。结论 Ｈｐ的感染可能和胃癌的发生有关，基因突变可能是Ｈｐ致胃癌的作用机制之一。
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| 关 键 词： | 幽门螺杆菌 胃肿瘤 病因学 癌基因 |
PRELIMINARYINVESTIGATION ON THE ROLE OF HELICOBACTER PYLORI IN GENESIS OF GASTRIC CANCER |
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| CAI Rong,REN Gang,CHEN Qiang et al. Tumor Center. PRELIMINARYINVESTIGATION ON THE ROLE OF HELICOBACTER PYLORI IN GENESIS OF GASTRIC CANCER[J]. Tumor, 2000, 20(3): 209-211 |
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| Authors: | CAI Rong REN Gang CHEN Qiang et al. Tumor Center |
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| Affiliation: | CAI Rong,REN Gang,CHEN Qiang et al. Tumor Center.Xinhua Hospital,Shanghai Second Medical University. Shanghai 200092,China |
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| Abstract: | Objective To determine the role of Helicobacter pylori(Hp)in the development of gastric cancer and gastric precancerous lesions.Methods The point mutation of cHaras and p53 genes was detected by polymerase chain reactionsingle strand conformation polymorphism analysis(PCRSSCP).Results The mutational rates of cHaras and p53 genes in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients,the mutational rates of cHaras and p53 genes in Hp positive patients were significantly higher than those of Hp negative patients.Conclusion Hp infection may be in relation with gastrocarcinogenesis,the gene mutation may play a role in Hp related gastric cancer. |
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| Keywords: | Bacteria Gastric neoplasms/etiology Oncogenes |
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