供精人工授精周期妊娠率相关因素及妊娠结局分析

目的:探讨影响供精人工授精周期妊娠率的相关因素及其妊娠结局.方法:对2005年11月至2007年10月在本中心治疗的594对不孕夫妇行1088个供精人工授精(AID)治疗周期.并分析不孕妇女的年龄、授精次数、治疗周期、促排卵等因素对AID治疗妊娠率的影响,并对AID治疗后妊娠结局进行统计分析.结果:①≥36岁组的周期妊娠率18.30%,与≤25岁组(30.37%)、26～30岁组(32.99%)、31～35岁组(27.10%)比较,差异有统计学意义(P<0.05);各年龄组自然流产率比较,差异无统计学意义(P>0.05),但有随年龄增高的趋势.②促排卵组与自然周期组行AID治疗,其周期妊娠率比较差异无统计学意义(P>0.05).③双次授精的周期妊娠率(34.34%)高于单次授精(20.05%)(P<0.05).④行AID治疗,不同治疗周期的周期妊娠率之间比较,差异无统计学意义(P>0.05).结论:供精人工授精周期妊娠率与多种因素有关,其中不孕妇女的年龄是影响AID成功率的重要因素.同一周期行两次人工授精能更有效控制授精时机,有较高周期妊娠率.

Analysis of the Parameters Affecting the Pregnancy Rate and the pregnant Re-suits in AID

Objective: To analyze the parameters affecting the pregnancy rate (PR) and pregnant results in artificial insemination by donor (AID) .Methods:Retrospective analysis of 594 infertile couples performed 1088 cycles of AID from November 2005 to October 2007 in our center. Pregnancy rates per cycle are presented as female age, insemination modality, no. of treatment cycles, and induction of ovulation or not. Pregnancy outcome was also evaluated by follow-up. Results:① The PR in female age ≥ 36 was 18.30%, significantly lower than that of age ≤ 25 group (30.37%),26-30 group (32.99%),and 31～35 group (27.10%) (P<0.05). However, no significant correlations were found in spontaneous abortion rate among each group ( P> 0.05). ② There were no statistical differences in PR between stimulation and natural cycle( P>0.05).③The PR of twice insemination per cycle(34.34%) was significantly higher than once insemination group (20.05%) ( P<0.05). ④ No significant differences were found in PR of each cycle ( P>0.05) .Conclusions: Multi-factors affect the pregnancy rate in AID. The female age was one of the most important factors affecting the pregnancy rate. Twice insemination per cycle could control the insemination occasion more efficiently and also improve the pregnancy rate.