声诺维在心内膜缘显像及心肌灌注中的效果评价

目的评价外周静脉注射造影剂声诺维对超声心动图心内膜缘显像的增强作用及其在心肌灌注中的效果。方法分别在基础和非线性成像条件下,对90例患者注射声诺维,用二维超声进行观察心内膜缘显像的改善,并观察非线性成像条件下心肌灌注情况及不良事件。结果造影剂在右心腔显影后很快在左心腔显影,原来显示欠清的左室心内膜缘得到满意的显影,声诺维能很好显示心肌灌注情况,无严重不良事件,不良事件总发生率为6．8％,其中可能由造影剂引起的不良事件发生率1．1％。结论声诺维可满意地增强心内膜缘的显影和显示心肌灌注,是一安全的跨肺循环的声学造影剂。

The effect of SonoVue in endocardial border delineation and myocardial perfusion

Objective To evaluate the enhancement of endocardial border delineation and displaying of myocardial perfusion by the contrast agent SonoVue intravenously.Methods Under mode of fundamental imaging and nonlinear imaging respectively, 90 patients were injected with SonoVue and observed for improvement of endocardial border delineation by two dimension echo.In the meantime, displaying of myocardial perfusion by SonoVue was also investigated under mode of nonlinear imaging. Adverse events were monitored. Results (1) SonoVue stained the left heart chambers of the patients right away after the right heart chambers had been stained. Endocardial border delinenation of the left heart in 90 patients were all improved by SonoVue. (2)SonoVue can well display myocardial opacification (3) No serious adverse events occurred throughout the study. All nonserious adverse events were minor, mild, and rapidly self-resolving. Total incidence of adverse events was 6.8% and the incidence of adverse events possibly related to SonoVue was 1.1%. Conclusion SonoVue is a safe transpulmonary agent and can satisfactorily improve the endocardial border delineation and show myocardial perfusion.