中风前抗轴突生长抑制因子DNA免疫促进脑缺血功能康复 |
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引用本文: | 朱兴宝,Jasmine Lee,Jill Wong,Wan Loo Tan,王廷华,冯忠堂,Xiao Zhicheng,Ivan Ng.中风前抗轴突生长抑制因子DNA免疫促进脑缺血功能康复[J].西南军医,2007,9(3):6-8. |
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作者姓名: | 朱兴宝 Jasmine Lee Jill Wong Wan Loo Tan 王廷华 冯忠堂 Xiao Zhicheng Ivan Ng |
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作者单位: | 1. 解放军昆明总医院神经外科,昆明650032;Brain Injury Research Lad,Department of Neurosurgery,National Neuroscience Institute,Singapore 408433;昆明医学院神经科学研究所,昆明650031;Institute of Molecular and Cell Biology Singapore 117608 2. Brain Injury Research Lad,Department of Neurosurgery,National Neuroscience Institute,Singapore 408433 3. 昆明医学院神经科学研究所,昆明650031 4. Institute of Molecular and Cell Biology Singapore 117608;Department of Anatomy,Faculty of Medicine,National University of Singapore,Singapore 119074;Department of Clinical Research,Singapore General Hospital,Singapore 169608 |
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基金项目: | 此课题得到新加坡国家卫生部和新加坡健康研究基金资助. |
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摘 要: | 目的证实中风前抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;血清中检测出相关抗体后,采用永久性阻断大脑中动脉的方法制备左侧局部脑缺血模型;分别采用改良的神经病严重程度记分、被动逃避试验和悬臂迷宫试验评价运动功能、认知行为和焦虑样情感的。结果中风前接受抗轴突生长抑制因子DNA免疫,局部脑缺血后出现明显的运动恢复,但是认知行为和焦虑样情感障碍则没有明显改善。结论中风前抗轴突生长抑制因子DNA免疫可促进脑缺血后的运动功能恢复。
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关 键 词: | 轴突生长抑制因子 DNA免疫 局部脑缺血 行为 |
文章编号: | 1672-7193(2007)03-0006-03 |
修稿时间: | 2007-01-31 |
Effect of Prestroke DNA immunization against Neurite Growth Inhibitors on the Neurological Improvement Following Permanent Local Cerebral Ischemia |
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Authors: | ZHU Xingbao Jasmine Lee Jill Wong Wan Loo Tan Wang Tinghua FENG Zhongtang XIAO Zhicheng Ivan Ng |
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Affiliation: | Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan Province 650032 |
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Abstract: | |
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Keywords: | neurite growth inhibitors DNA immunization local cerebral ischemia behavior |
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