| 羟化酶抑制剂与抗生素在诺卡菌选择性氧化胆甾醇中的作用 |
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| 引用本文： | 褚志义,周佩,王黎明,程务本,莫国强.羟化酶抑制剂与抗生素在诺卡菌选择性氧化胆甾醇中的作用[J].复旦学报(医学版),1987(4). |
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| 作者姓名： | 褚志义 周佩 王黎明 程务本 莫国强 |
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| 作者单位： | 上海医科大学药学院生物合成药物化学教研室
(褚志义，周佩，王黎明)，仪器分析中心实验室
(程务本)，仪器分析中心实验室(莫国强) |
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| 摘 要： | 采用了羟化酶抑制剂8-羟基喹啉和113种抗生素来研究提高诺卡菌8401选择性地氧化胆甾醇3位羟基为酮基的专一性。实验结果指出:8-羟基喹啉能促使选择性氧化比对照提高7.38％;在前基础上加氨苄青霉素比对照提高77.8％,加头孢唑啉比对照提高51.3％,而加其他抗生素起负效应作用。
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| 关 键 词： | 诺卡菌 胆甾醇 胆甾-4-烯-3-酮 8-羟基喹啉 诺卡菌的选择性氧化 羟化酶抑制剂 氨苄青霉素 |
THE EFFECT OF ANTIBIOTICS AND AN INHIBITOR OF HYDROXYLASE ON SELECTIVE NOCARDIA OXIDATION OF CHOLESTEROL |
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| Chu Zhiyi,Zhou Pei,Wang Liming,Oheng Wuben,Mo Guoqiang.THE EFFECT OF ANTIBIOTICS AND AN INHIBITOR OF HYDROXYLASE ON SELECTIVE NOCARDIA OXIDATION OF CHOLESTEROL[J].Fudan University Journal of Medical Sciences,1987(4). |
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| Authors: | Chu Zhiyi Zhou Pei Wang Liming Oheng Wuben Mo Guoqiang |
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| Abstract: | We found that nooardia sp. 8401 can transform cholesterol to cholest-4-ene-3-one.The control of selective oxidation was studied by addition of 13 antibiotics and an inhibitor of hydroxylase, 8-hydroxyquinolin.Experimental results indicated that addition of 8-hydroxyquinolin raised conversion by 7.38 %. Further addition of ampiciilin raised conversion by 77.8 % and cefazolin raised conversion by 51.3%, other antibiotics all caused depression of conversion. |
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| Keywords: | nocardia cholesterol eholest-4-ene-3-one 8-hydroxyqninolin selective nocardia oxidation inhibitor of hydroxylase ainpieillin |
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