甲泼尼龙与丙种球蛋白联合治疗成人急性播散性脑脊髓炎的疗效 |
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引用本文: | 李瞿,张朝东.甲泼尼龙与丙种球蛋白联合治疗成人急性播散性脑脊髓炎的疗效[J].实用药物与临床,2009,12(5):365-366. |
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作者姓名: | 李瞿 张朝东 |
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作者单位: | 中国医科大学附属第一医院神经内科,沈阳,110001 |
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摘 要: | 目的评价甲泼尼龙与丙种球蛋白联合治疗成人急性播散性脑脊髓炎(ADEM)的临床疗效。方法对42例诊断为ADEM的成人患者进行回顾性研究,按主要的治疗方法分为甲泼尼龙加丙种球蛋白(MPS+IG)组及甲泼尼龙(MPS)组,以2组患者Kurtzke神经功能障碍量表(EDSS)评分反映疗效,比较两组治疗7d、15d的EDSS评分及复发情况。结果治疗7d时MPS+IG组的EDSS评分为2.7±1.5,明显低于MPS组的EDSS评分3.8±1.7(P<0.05),治疗15d时两组的EDSS评分及随访期间的复发病例差异均无统计学意义(P>0.05)。结论甲泼尼龙与丙种球蛋白联合治疗成人ADEM在治疗早期可明显改善临床症状,加快病情好转,效果优于单用甲泼尼龙治疗。
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关 键 词: | 急性播散性脑脊髓炎 丙种球蛋白 甲泼尼龙 |
Effect of methylprednisolone combined with immunoglobulin in the treatment of adult patients with acute disseminated encephalomyelitis |
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Abstract: | Objective To evaluate the effect of methylprednisolone combined with immunoglobulin on adult patients with acute disseminated encephalomyelitis(ADEM).Methods A retrospective study was conducted in 42 adult patients with the diagnosis of ADEM.The patients were divided into two groups:methylprdnisolone combined with immunoglobulin group(MPS+IG),and methylprednisolone group(MPS).The effects of 2 groups were compared by the scores of Kurtzke expanded disability status scale(EDDSS)before and after therapy,as well as the recurrent cases.Results The EDSS scores in MPS+IG group and MPS group were(2.7±1.5)and(3.8±1.7)respectively,after 7 d of treatment,there were statistical differences between them(P<0.05).But there was no significant difference between them in EDSS scores after 15 d of treatment,as well as the recurrent cases(P>0.05).Conclusion Methylprednisolone combined with immunoglobulin on adult patients with ADEM prevails in short-term efficacy. |
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Keywords: | Acute disseminated encephalomyelitis Methylprednisolone Immunoglobulin |
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