早发冠心病中医证型与C反应蛋白、血尿酸相关性研究

目的:探讨早发冠心病(premature coronary heart disease,PCHD)中医证型与C反应蛋白(CRP)及血尿酸(UA)的相关性。方法:196例经冠状动脉造影确诊为冠心病的患者(男<55岁,女<65岁),中医辨证为心血瘀阻证(58例)、痰浊闭阻证(55例)、非痰瘀证(83例),另选健康对照组57例,检测三组CRP、UA含量。结果:①CRP含量的比较:与健康对照组相比,PCHD组血浆CRP含量明显增高,差异有统计学意义(P<0.05);其中心血瘀阻证及痰浊闭阻证组与非痰瘀证组比较血浆CRP含量增高,差异有统计学意义(P<0.05);痰浊闭阻证组与心血瘀阻证组比较血浆CRP含量无差异(P>0.05)。②血尿酸含量比较:与健康对照组相比,PCHD组血浆UA含量明显增高,差异有统计学意义(P<0.05);PCHD三组之间UA含量无明显差异(P>0.05)。结论:CRP水平与PCHD中医证型存在相关性,可作为PCHD中医辨证分型辅助诊断的客观指标。

Relative research between premature coronary syndromes and C-reactive protein,serum uric acid

Objective：To observe the relationship between premature coronary syndromes and C-reactive protein, serum uric acid. Methods：196 patients were divided into 58 cases of Xinxue Yuzhu syndrome, 55 cases of Tanzhuo Bizu syndrome, 83 cases of Feitan yu syndrome. 57 patients were selected as control group. Results： ①CRP content was higher with stastical difference in PCHD group （P〈0.05）;CRP content was higher of Xinxue Yuzu/Feitan Yuzu and Tanzhuo Bizu/Feitan Yuzu;CRP content has no stastical difference of Tanzhuo Bizu/Xinxue yuzu （P〈0.05）; ②Blood UA content was obviously higher in PCHD group with stastical difference （P〈0.05）;UA content has no obvious difference in three groups （P〈0.05）. Conclusion：There is a relationship between premature coronary syndromes and C-reactive protein, serum uric acid and can be used as a index for TCM differentiation.