Nitrosamines and nitrosamine precursors in foods from Linxian, China, a high incidence area for esophageal cancer |
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Authors: | G M Singer J Chuan J Roman L Min-Hsin W Lijinsky |
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Affiliation: | LBI-Basic Research Program, Laboratory of Chemical and Physical Carcinogenesis, NCI-Frederick Cancer Research Facility Frederick, MD 21701, USA. 1Cancer Insitute, Chinese Academy of Medical Sciences Beijing, People's Republic of China 2Program Resources. Inc., NCI-Frederick Cancer Research Facility Frederick, MD 21701, USA |
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Abstract: | Nitrosamines and precursor secondary amines were assayed infoods from families in four villages of the esophageal cancerhigh incidence area of Linxian, Henan Province, People's Republicof China. Amines (as tosyiamides) and nitrosamines were readilydetected at p.p.m. and p.p.b. levels, respectively, in all samples.In this small preliminary survey (25 families, four villages),however, there were no strong correlations between the levelsof the carcinogenic nitrosamines or the precursor secondaryamines with the incidence of esophageal cancer in the individualfamilies. The success of the analytical procedures suggeststhat a more extensive study is warranted. |
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