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18例蕈样肉芽肿临床分析
引用本文:王向东,夏治华,沈宏,许爱娥. 18例蕈样肉芽肿临床分析[J]. 中国中西医结合皮肤性病学杂志, 2005, 4(2): 92-94
作者姓名:王向东  夏治华  沈宏  许爱娥
作者单位:杭州市第三人民医院,杭州,310009
摘    要:目的探讨蕈样肉芽肿(MF)各期的临床、病理表现,治疗方案.方法复习了18例MF的临床和实验室资料(红斑期3例,斑块期9例,肿瘤期6例).结果红斑期表现为红斑、丘疹,病理无特异性.斑块期表现为鳞屑性肥厚性斑块,或色素减退性白斑,病理表现为真皮乳头血管周围异形淋巴细胞的灶状浸润.肿瘤期表现为局部或全身性斑块、结节、破溃,病理表现真皮内异形淋巴细胞片状或弥漫性浸润,可累及皮下组织.干扰素等治疗对红斑期和斑块期患者有效,肿瘤期患者则局部和系统化疗有效.结论红斑期患者皮疹及病理无特异性,治疗反应好,斑块期及肿瘤期患者皮疹、病理均有特异性,肿瘤期患者治疗疗效欠佳.

关 键 词:蕈样肉芽肿  临床病理  治疗
文章编号:1672-0709(2005)02-0092-03
修稿时间:2004-12-20

Clinical Analysis of 18 Cases of Mycosis Fungoides
WANG Xiang-dong,XIA Zhi-hua,SHEN Hong,XU Ai-e. Clinical Analysis of 18 Cases of Mycosis Fungoides[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2005, 4(2): 92-94
Authors:WANG Xiang-dong  XIA Zhi-hua  SHEN Hong  XU Ai-e
Abstract:Objective To explore the clinical, pathological manifestations and therapeutic regimen in different stages of mycosis fungoides (MF). Methods To review the clinical and laboratory data of 18 cases of MF, which included 3 cases in erythema stage, 9 cases in plaque stage and 6 cases in tumor stage. Results The main manifestations in erythema stage were erythema, papules, and showed no special changes in histolgogy. The main manifestations in plaque stage were squamous and hypertrophic plaques, or depigmentation maculae. The pathological manifestations were solitary infiltration of allotypic lymphocytes around papillary dermis vascellum. And the manifestations in tumor stage were plaques, nodules and diabrosis in local or all over the body. The pathological manifestations were lamellar and diffused infiltration of allotypic lymphocytes in dermis, and subcutaneous tissue was also involved. Interferon took effective on the patients in erythema stage, while local and systematic chemotherapy were benefit for in tumor stage. Conclusion Rashes and histology showed no special changes and were responsed well to therapy in erythema stage. Both rashes and histology were distinctive changed in plaque and tomor stage. The patients in tumor stage were reluctant to clinical therapy.
Keywords:mycosis fungoides  clinic pathology  therapy?allQ
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