Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma |
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| Authors: | Masashi Ogawa Maho Morikawa Masaki Kobatake Taku Murakami Yuki Yamamoto Rikiya Watanabe Katsumi Yamada Katsuhito Nishiyama Yoshiro Yasutomo Kenta Hara |
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| Affiliation: | 1.Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan; 2.Department of Diagnostic Pathology, Kita-Harima Medical Center, Japan; 3.Department of Internal and Geriatric Medicine, Kita-Harima Medical Center, Japan |
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| Abstract: | An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)2VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25(OH)2VitD in DLBCL ectopically expressing 1α-hydroxylase. |
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| Keywords: | calcium, 1,25(OH)2VitD, 1α -hydroxylase, CYP27B1, lymphoma |
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