An intravascular perspective on hyper-acute neutrophil,T-cell and
platelet responses: Similarities between human and experimental
stroke |
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Authors: | Guido Stoll Michael K Schuhmann Bernhard Nieswandt Alexander M Kollikowski Mirko Pham |
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Affiliation: | 1.Department of Neurology, University of Würzburg, Würzburg, Germany; 2.Institute for Experimental Biomedicine and Rudolf-Virchow-Center, University of Würzburg, Würzburg, Germany; 3.Department of Neuroradiology, University of Würzburg, Würzburg, Germany |
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Abstract: | In stroke patients, local sampling of pial blood within the occluded vasculature before recanalization by mechanical thrombectomy emerged as powerful tool enabling insights into ultra-early stroke pathophysiology. Thereby, a strong intravascular inflammatory response hallmarked by hyper-acute neutrophil recruitment, altered lymphocyte composition and platelet activation could be observed. These human findings mirror experimental stroke. Here, neutrophil and T-cell activation are driven by platelets involving engagement of platelet glycoprotein receptor (GP)Ib, GPVI and CD84 as well as α-granule release orchestrating infarct progression. Thus, targeting of early intravascular inflammation may evolve as a new therapeutic strategy to augment the effects of recanalization. |
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Keywords: | Cerebral ischemia pial blood sampling platelet activation neuroinflammation DAMPs |
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