Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report |
| |
| Authors: | Francesco Colombo Ali Waheed Sandro Panese Claudio Scarparo Maria Solinas Saverio Giuseppe Parisi Nicholas Geremia |
| |
| Affiliation: | 1.Department of Molecular Medicine, University of Padova, Padua, Italy; 2.Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale dell’Angelo, Venice, Italy; 3.Unit of Microbiology and Virology, Ospedale dell’Angelo, Department of Medical Direction, Ospedale “dell’Angelo”, Venice, Italy |
| |
| Abstract: | SUMMARYWe report the case of successful use of cefiderocol (FDC) in a Carbapenemase Producing K. pneumoniae (CPKP) post-surgical meningitis in a 44-year-old man treated with antimicrobial therapy and external ventricular drainage (EVD). The patient was known for being colonised by CPKP; for this reason, therapy with ceftazidime/avibactam (CZA) plus fosfomycin and linezolid was started. After an initial response a CZA resistant CPKP strain was isolated from CSF culture, so the antibiotic therapy was modified to FDC with trimethoprim/sulfamethoxazole for 14 days, and EVD was replaced. A complete recovery was obtained. This is the first case report describing FDC administration in CPKP meningitis. |
| |
| Keywords: | cefiderocol meningitidis enterobacterales Klebsiella pneumoniae carbapenemase |
|
|
