Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis |
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| Authors: | Kayoko Kaneko Toshihiro Nanki Tadashi Hosoya Fumitaka Mizoguchi Nobuyuki Miyasaka |
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| Affiliation: | (1) Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;(2) Department of Pharmacovigilance, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan; |
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| Abstract: | We present two patients with rheumatoid arthritis (RA) who developed necrotizing crescentic glomerulonephritis (NCGN) during etanercept therapy. Both patients developed proteinuria and hematuria, and one progressed to renal failure. Renal biopsy revealed NCGN. In both patients, nephritis improved following discontinuation of etanercept and administration of prednisolone. Physicians should be aware of etanercept-induced GN in patients with RA on anti-tumor necrosis factor therapy. |
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