Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip |
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Authors: | Yoko Yamanishi Shinya Sakuma Kazuhisa Onda Fumihito Arai |
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Institution: | (1) Japan Science & Technology Agency (JST), PRESTO, Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 Aichi-ken, Japan;(2) Department of Bioengineering and Robotics, Tohoku University, 6-6-01, Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi-ken 980-8579, Japan;(3) Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603 Aichi-ken, Japan |
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Abstract: | This paper describes a novel powerful noncontact actuation of a magnetically driven microtool (MMT), achieved by magnetization
of the MMT and focusing of the magnetic field in a microfluidic chip for particle sorting. The following are the highlights
of this study: (1) an MMT was successfully fabricated from a mixture of neodymium powder and polydimethylsiloxane; the MMT
was magnetized such that it acted as an elastic micromagnet with a magnetic flux density that increased by about 100 times
after magnetization, and (2) a pair of sharp magnetic needles was fabricated adjacent to a microchannel in a chip by electroplating,
in order to focus the magnetic flux density generated by the electromagnetic coils below the biochip; these needles contribute
to miniaturization of an actuation module that would enable the integration of multiple functions in the limited area of a
chip. FEM analysis of the magnetic flux density around the MMT showed that the magnetic flux density in the setup with the
magnetic needles was around 8 times better than that in the setup without the needles. By magnetization, the drive frequency
of the MMT improved by about 10 times—from 18 Hz to 180 Hz. We successfully demonstrated the separation of copolymer beads
of a particular size in a chip by image sensing. |
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