Mechanisms of apoptosis in central nervous system tumors: Application to theory |
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| Authors: | Joachim P Steinbach Michael Weller |
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| Institution: | (1) Laboratory of Molecular Neuro-Oncology, Department of Neurology, University of Tübingen, Medical School, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany |
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| Abstract: | Apoptosis is a key concept for the successful therapy of brain tumors. This review focuses on the mechanisms of apoptosis
occurring spontaneously in malignant gliomas, discusses the different methods employed to assess apoptosis in vivo and in
vitro, and considers the value of quantifying apoptosis in surgical biopsies for diagnosis and prognosis. Further, novel strategies
to induce apoptosis in human malignant glioma cells are reviewed, including experimental therapy with death ligands, methods
for sensitizing glioma cells to the induction of apoptosis, p53 gene transfer, and approaches to target the expression of
therapeutic genes selectively to tumor cells. |
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