Facilitation of neurotransmitter release in mouse motor synapses in different modes of protein kinase C activation |
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Authors: | A E Gaydukov A A Marchenkova O P Balezina |
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Institution: | Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. gaydukov@gmail.com. |
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Abstract: | Protein kinase C blocker chelerythrine prevented the increase in quantal content of single and rhythmic evoked end-plate potentials after disinhibition of L-type Ca(2+)-channels with paxillin. Phorbol ester increased quantal content of single end-plate potentials and changed rhythmic activity of mouse motor synapses. The effects of phorbol ester were to a great extent neutralized by L-type Ca(2+)-channel blocker nitrendipine and were completely abolished by K(+)-channel blocker 4-aminopyridine. Thus, we discovered different facilitations of transmission after protein kinase C activation with calcium current through L-type channels and with phorbol ester. |
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