感觉神经定量检测仪对糖尿病患者检测的临床意义初步观察

目的 探讨血脂异常与糖尿病周围神经病变（DPN）的相关性. 方法 将201例患者按照是否合并血脂异常分为单纯T2DM组68例、T2DM合并血脂异常组66例、单纯血脂异常组32例和健康对照（NC）组35名,采用感觉神经定量检测仪测定各组正中、腓肠神经于2000、250、5 Hz的电流感觉阈值（CPT）,检测相关生化指标. 结果 T2DM合并血脂异常组较单纯T2DM组CPT升高（P＜0.05）,5 Hz时CPT升高最显著（P＜0.01）.单纯T2DM组和单纯血脂异常组双侧正中、腓肠神经比较差异无统计学意义.单纯血脂异常组双侧正中、腓肠神经CPT较NC组升高（P＜0.05或P＜0.01）. 结论 血脂异常与高糖毒性是DPN的两个等位危险因素,高糖合并血脂异常可加快DPN发生发展.

A preliminary observation on clinical significance of quantitative sensory testing instrument for diabetic patients

Objective To explore the relationship between dyslipidemia and diabetic peripheral neuropathy （DPN）. Methods 201 patients were divided into T2DM group with 68 patients, T2DM with dyslipidemia group with 66 patients, dyslipidemia group with 32 patients and normal control （NC） group with 35 subjects. Using the Neurometer, current perception thresholds （CPT） testing at 2000, 250 and 5 Hz was performed on median and peroneal nerves. Biochemical parameters of the above four groups were tested. Results Compared with T2DM group, the CPT in T2DM with dyslipidemia group was significantly higher （P〈0.05）, especially at low {requency （5 Hz, P〈0. 01）. There was no CPT difference between T2DM group and dyslipidemia group. Compared with NC group, the CPT in dyslipidemia group was higher （P〈0. 05 or P〈0.01）. Conclusion Hyperglycemia and dyslipidemia are two important risk factors leading to DPN. Hyperglycemia combined with dyslipidemia can accelerate the happening and development of DPN.