川白芷提取物异欧前胡素大鼠体内药动学研究

目的探讨经灌胃给药后川白芷提取物异欧前胡素大鼠体内的药物动力学特征。方法采用高效液相色谱法，测定灌胃给药后大鼠血浆中异欧前胡素血药浓度变化，用DAS2．0药动学软件处理，计算其药物动力学参数。结果异欧前胡素在大鼠体内过程符合二室模型特征，主要药动学参数为Tmax=（1．6±0．000）h，Cmax=（15．842±0．35）mg／L，AUC0-t=（80．761±10．03）mg／（L·h），AUC0-∞=（89．45±9．34）mg／（L·h），t1／2=（5．101±0．24）h。结论该方法适用于异欧前胡素的药物动力学研究。

Phamacokinetic Study of Isoimperatorin in Rats After Drug Administration

Objective To establish a HPLC method for the determnation of serum concentration of isoimperatorin in rats and study pharmacokinetic characteristic of isoimperatorin in rat after drug admiaistraction. Method The concentrations of isoimperatorin in rats were determined after drug administration and the pharmacokinetic parameters of isoimperatorin were estimated by DAS2.0 computer program. Result The concentration-time profiles were fitted with open two compartment model system. The main pharmacokinetic parameters were as follows： Tmax =（1.6±0.000）h, Cmax =（15.842＋0.35）mg/L, AUC0-t=（80.761 ± 10.03）mg/（L· h）, AUC0-∞=（89.45±9.34）mg/（L · h）, t1/2=（5.101±0.24）h. Conclusion The method is appropriate for the determination and pharmacokinetic study of isoimperatorin in rats after drug administration.