青阳参化学成分的研究

昆明产的青阳参(Cynonchum otophyllum Schneid.)经药理和临床实验证明,对癫痫和迁慢性肝炎有较好的疗效。本文报道从青阳参根中分得两种甾体酯甙元和一个去氧糖,分别鉴定为告达亭(caudatin Ⅰ),青阳参甙元(qingyangshengenin Ⅱ)和地芰糖(digitoxose Ⅲ),其中Ⅱ为新化合物。

THE CONSTITUENTS OF QING YANG SHEN (CYNANCHUM OTOPHYLLUM SCHNEID.)

OING YANG SHEN (Cynanchum otophyllum Schneid, Asclepiadaceae) is a plant widely distributed in southwest China. In Yunnan, its root is used as nourishing and roborant drug and in the treatment of convulsions of the child. The result of pharmacological study showed that the root of OING YANG SHEN has anticonvulsant action and therapeutic activity for chronic hepatitis.Two aglycones and one sugar were obtained from the hydrolysate of the crude glycoside by sillica column chromatography. On the basis of spectra, analysis (UV. IR. MS. ¹HNMR. and ¹³CNMR.), preparation of derivatives and chemical reactions, two of them were i dentifed as caudatin (Ⅰ) and digitoxose (Ⅲ). The third component was a new compound, its structure was established as C/D cis, △⁵, 3β, 8β, 14β, 17β- tetrahydroxy-12-O- p-hydroxybenzoylpregnan- 20-one, and named qingyangshengenin (Ⅱ).