2-硫脲嘧啶对高脂血症大鼠血液流变学特性的影响

目的观察2．硫脲嘧啶对高脂血症大鼠模型血液流变学特性的影响。方法采用0．5％的胆盐和4％的胆固醇加入基础饲料建立高脂血症模型，观察2．硫脲嘧啶对模型大鼠血浆甘油三酯（TG）、总胆固醇（Tc）、低密度脂蛋白胆固醇（LDL．C）、高密度脂蛋白胆固醇（HDL．C）、血糖（Glu）、全血表观粘度（ ηb）、全血还原粘度（ ηre）、血浆粘度（ ηp）、红细胞压积（Hct）、红细胞电泳率、红细胞的变形、取向指数、红细胞聚集等流变学特性的影响。结果与对照组相比，高脂组TC、TG、LDL．C、GIu、红细胞聚集指数、全血表观粘度、全血还原粘度明显增高，HDL．C、红细胞的变形及取向指数、、红细胞电泳率降低；与高脂组相比，甲减组大鼠TC、TG、LDL．C、Glu、红细胞聚集指数、全血还原粘度增高，HDL．C、红细胞的变形及取向指数、红细胞电泳率降低、全血表观粘度降低。结论2．硫脲嘧啶能够升高血糖血脂，恶化血液流变学指标。

The Effect of 2-thiouracil on Hemorheology of Rats with Hyperlipemia

Objective To investigate the effects of 2-thiouracil on hemorheology of hyperlipedic rats.Methods Establishing the model of MS with CC diet （0.5% acid salt,4% cholesterol）,and observing the effects of 2-thiouracil on rheological characteristic including erythrocyte electrophoresis and deformation index,orientation index,and aggregation index.Result Compared with C group, TG,TC,LDL-C,Glucose, η b, η p, η re and aggregation index increase, HDL-C,erythrocyte electrophoresis,deformation index and orientation index decrese;Compared with H- group,TG,TC,LDL-C,Glucose, η b, η p, η re and aggregation index increase significantly, HDL-C, erythrocyte electrophoresis,deformation index and orientation index decrese significantly.Conclusion 2-thiouracil can increase high glucose and high fat,and deteriorate rheological index.