经纤维支气管镜局部化疗治疗晚期肺癌

目的 观察经纤维支气管镜（纤支镜）局部化疗加全身静脉化疗治疗气道阻塞晚期肺癌患的疗效。方法 ①将４０例晚期肺癌患，随机分为观察组（２０例）与对照组（２０例）。观察组采用Ｏｌｙｍｐｕｓ ＢＦ及配套的ＮＭ－３Ｋ型注射针注入卡铂３００ｍｇ至瘤体中央及周围并卡铂、依托泊甙（ＣＥ方案）常规化疗。对照组单纯用ＣＥ方案化疗。结果 观察组２０例中，完全缓解７例（３５％），部分缓解１１例（５５％），无变化２例（

Localchemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma

Objective To observe the effectiveness of treatment in the patients with advanced bronchogenic carcinoma of local chemotherapy with fibrobronchoscopy, combined with systematic chemotherapy. Methods 40 patients with advanced bronchogenic carcinoma were divided into the tested group (20 patients) and the control group (20 patients) randomly. By fibrobronchoscopy with its matched injecting needle, carboplatin 300 mg were injected into the centre of the tumor and the surroundings, combined with the routine carboplatin and etoposide (CE) regimen. While the control group was treated only by intravenous chemotherapy with the routine CE regimen. Results In the 20 patients with local chemotherapy by fibrobronchoscopy combined with intravenous chemotherapy, 7 cases (35%) were completely cured and 11 cases (55%) showed partial recovery, other 2 cases without change. The 90% effective rate was significantly higher than 55% of the control group ( P <0.05). Conclusions The local chemotherapy by fibrobronchoscopy can remarkably reduce the size of tumor, and relieve symptom of dyspnea. Intravenous chemotherapy alleviated the obstruction caused by tracheal or bronchial neoplasms. The combined therapies led to much better therapeutic effect and symptomatic relief than those by the routine CE regimen.