| VIM方案治疗复发与难治性非霍奇金淋巴瘤 |
| |
| 引用本文： | 李小琴,朱小霞,顾汉刚,李文军.VIM方案治疗复发与难治性非霍奇金淋巴瘤[J].现代肿瘤医学,2002,10(2):106-106. |
| |
| 作者姓名： | 李小琴 朱小霞 顾汉刚 李文军 |
| |
| 作者单位： | 镇江医学院附属医院,江苏,镇江,212001 |
| |
| 摘 要： | 目的 观察VIM方案 (足叶乙甙、异环磷酰胺、米托蒽醌 )治疗复发与难治性非霍奇金淋巴瘤(non -Hodgkinlymphoma ,NHL)的疗效与毒性。方法 40例中高度恶性NHL ,8例难治性 ,32例 2次以上复发。治疗方案 :足叶乙甙 (VP - 16 ) 6 5mg/m2 、异环磷酰胺 (IFO) 1.0g/m2 静滴 ,d1-3 ;米托蒽醌 (MIT) 8mg/m2 静注 ,d1。结果 总缓解率 5 5 % (7例CR ,15例PR)。缓解期 2～ 2 9月 ,中位缓解期 2 5月。毒性反应主要是骨髓抑制 ,大多数为Ⅰ、Ⅱ度。结论 VIM方案治疗复发与难治性NHL较安全有效。
|
| 关 键 词： | 淋巴瘤 非霍奇金淋巴瘤 足叶乙甙 异环磷酰胺 米托蒽醌 |
| 文章编号： | 1008-7001(2002)02-0106-02 |
| 修稿时间： | 2001年10月31 |
Etoposide-ifosfamide-mitoxantrone regimen in treatment of relapsed and refractory non-Hodgkin Lymphoma |
| |
| LI Xiao-qin,ZHU Xiao-xia,GU Han-gang,et al..Etoposide-ifosfamide-mitoxantrone regimen in treatment of relapsed and refractory non-Hodgkin Lymphoma[J].Journal of Modern Oncology,2002,10(2):106-106. |
| |
| Authors: | LI Xiao-qin ZHU Xiao-xia GU Han-gang |
| |
| Institution: | LI Xiao-qin,ZHU Xiao-xia,GU Han-gang,et al . Department of Medical Oncology,Affiliated Hospital of Zhenjiang Medical College,Zhenjiang 212001,China |
| |
| Abstract: | Objective The current study was designed to observe the efficacy and toxicity of etoposide,ifosfamide and mitoxantrone (VIM) regimen for relapsed and refractory non-Hodgkin's lymphoma. Methods Forty patients with intermediate or high-grade lymphoma were selected as sabjects. Eight patients had refractory disease,the others were relapsed more than twice.All patients received VP-16 65mg/m2,IFO 1.0g/m2 on day 1 to 3 and MIT 8mg/m2 on day 1. Results Overall response rate was 55% (7CR and 15PR) with a median duration of 25 months (range:2-29).The main toxicity was mild mylosuppression. Conclusion The VIM regimen is efficent and safe. |
| |
| Keywords: | lymphoma non-Hodgkin etoposide ifosfamide mitoxantrone |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
